U.S. stock futures inched higher on Wednesday as traders monitor the latest developments in the Middle East and brace for the Federal Reserve’s latest rate policy decision. S&P 500 futures rose 0.1%, while Nasdaq 100 futures advanced 0.2%. Futures tied to the Dow Jones Industrial Average also climbed 22 points, or about 0.1%. Stocks are coming off a downbeat session Tuesday as the Israel-Iran conflict mounted. The attacks between the two countries entered their sixth day Wednesday as Iran’s supreme leader, Ayatollah Ali Khamenei, said that Iran won’t surrender and warned that the U.S. will “undoubtedly be met with irreparable damage” if it enters the conflict. This comes after President Donald Trump took to his Truth Social platform Tuesday to threaten the Iranian leader, saying that “our patience is wearing thin” and calling for “UNCONDITIONAL SURRENDER!” Current and former administration officials also told NBC News that Trump is weighing options on Iran, including whether to launch a military strike. Adam Crisafulli, founder of Vital Knowledge, said that equity markets are looking especially vulnerable these days. “Even before the events in the Middle East, there was just so much risk on the horizon, and we have valuations that are very elevated so you don’t have a lot of flexibility,” he said Tuesday on CNBC’s “Closing Bell,” noting that tariffs, fiscal uncertainty and the debt ceiling are among the factors that are up in the air. “There’s not a lot of capacity priced in to absorb all this uncertainty.” The Federal Reserve’s rate decision is due at 2 p.m. ET. The U.S. central bank is widely expected to hold rates steady, but investors will be keeping a close eye on Fed Chair Jerome Powell’s post-meeting comments. Traders are also watching for policymakers’ forecast on rate policy, as the Federal Open Market Committee will be sharing members’ “dot plot” of rate expectations. U.S. Treasury yields were little changed on Wednesday as investors awaited the Federal Reserve’s rate policy decision and more insight on the economic impact of President Donald Trump’s tariffs and escalating tensions in the Middle East. The benchmark 10-year Treasury note fell 2 basis points to 4.371%. The 2-year Treasury yield also slipped less than 1 basis point to 3.941%. Asia-Pacific markets traded mixed Wednesday, as escalating tensions between Israel and Iran weigh on investor sentiment. Japan’s benchmark Nikkei 225 added 0.9% to close at 38,885.15, and the Topix rose 0.77% to end the trading day at 2,808.35. South Korea’s Kospi climbed 0.74% to close at 2,972.19 and the small-cap Kosdaq was 0.53% higher at 779.73. Australia’s S&P/ASX 200 lost 0.12% to close at 8,531.2. Hong Kong’s Hang Seng index lost 1.12% to close at 23,710.69, while mainland China’s CSI 300 was up 0.12% to end the trading day at 3,874.97. U.S. crude oil futures remained near five-month highs on Wednesday as President Donald Trump weighed whether to join Israel’s air campaign against Iran’s nuclear facilities. U.S. crude oil futures were up 12 cents to $74.96 a barrel, while global benchmark Brent rose 5 cents to $76.50 per barrel. Oil prices gained more than 4% on Tuesday after Trump threatened Iran’s supreme leader, Ayatollah Ali Khamenei, and demanded that his regime surrender  unconditionally. Gold prices edged lower on Wednesday as investors refrained from making significant bets ahead of the U.S. Federal Reserve’s policy decision, while keeping a close watch on escalating developments in the Israel-Iran conflict. Spot gold dipped 0.1% to $3,386.79 an ounce. U.S. gold futures fell 0.1% to $3,405.10.